---
title: "Frontier Orbitals and Reactivity"
book: "University Chemistry — Year 2"
subject: chemistry
language: en
chapter: 17
exercises: 12
source: https://one-course.com/books/chemistry/3/en/chapter/17-frontier-orbitals-and-reactivity
license: CC-BY-NC-SA-4.0
credit: "One Chemistry Book, One Course (one-course.com)"
---

# Chapter 17 — Frontier Orbitals and Reactivity

A bottle of cyclopentadiene left on the shelf slowly turns into its dimer: two molecules of the same [diene](#def-b2-frontier-orbitals-diels-alder) join into a bridged bicyclic compound, and only one of the possible stereoisomers forms. Nothing in the curly arrows of the Year 1 volume predicts which. Two orbitals do: the highest occupied orbital of one molecule and the lowest empty orbital of the other. This chapter turns the two-level interaction of [Chapter 14](https://one-course.com/books/chemistry/3/en/chapter/14-molecular-orbitals-of-diatomic-molecules#ch-b2-diatomic-mos) into a tool for reactivity — which atom a nucleophile attacks, from which side, and why a [diene](#def-b2-frontier-orbitals-diels-alder) and an alkene combine into a ring in a single step.

**You already know.**

[Chapter 14](https://one-course.com/books/chemistry/3/en/chapter/14-molecular-orbitals-of-diatomic-molecules#ch-b2-diatomic-mos): two interacting orbitals, four-electron repulsion. [Chapter 16](https://one-course.com/books/chemistry/3/en/chapter/16-huckel-theory-and-conjugated-systems#ch-b2-huckel): Hückel levels and coefficients of conjugated systems. The Year 1 volume: nucleophiles and electrophiles, curly arrows, kinetic control, stereospecific, stereoselective and regioselective reactions, electrophilic additions to alkenes, nucleophilic substitution.

## 17.1 Two orbitals, revisited

When two molecules approach, their orbitals overlap and interact. Most of the interaction is weak, the orbitals being far apart in energy; a perturbative form of the two-level result then suffices.

**Theorem 17.1 (Weak interaction of two levels).**

Two orbitals of energies $\varepsilon_1 < \varepsilon_2$, coupled by a [resonance integral](https://one-course.com/books/chemistry/3/en/chapter/14-molecular-orbitals-of-diatomic-molecules#def-b2-diatomic-mos-integrals) $\beta$ with $|\beta| \ll \Delta\varepsilon = \varepsilon_2 - \varepsilon_1$ (overlap neglected), are shifted to

$$
\varepsilon_1 - \frac{\beta^2}{\Delta\varepsilon}, \qquad \varepsilon_2 + \frac{\beta^2}{\Delta\varepsilon}
$$

to first order in $\beta^2/\Delta\varepsilon^2$: the lower level falls and the upper rises by the same amount, the smaller as the gap is larger.

**Proof.** By [Theorem 14.14](https://one-course.com/books/chemistry/3/en/chapter/14-molecular-orbitals-of-diatomic-molecules#thm-b2-diatomic-mos-heteronuclear) the exact levels are $\bar\varepsilon \mp
\sqrt{\Delta\varepsilon^2/4 + \beta^2}$. With $u = 4\beta^2/\Delta\varepsilon^2 \ll 1$, $\sqrt{\Delta\varepsilon^2/4
+ \beta^2} = \frac{\Delta\varepsilon}{2}\sqrt{1 + u} \approx \frac{\Delta\varepsilon}{2}(1 + u/2) =
\frac{\Delta\varepsilon}{2} + \frac{\beta^2}{\Delta\varepsilon}$, and $\bar\varepsilon \mp \Delta\varepsilon/2 = \varepsilon_1,
\varepsilon_2$. ∎

**Proposition 17.2 (Two electrons attract, four repel).**

If the two interacting orbitals hold two electrons in all, the system is stabilised by about $2\beta^2/\Delta\varepsilon$. If they hold four, the system is destabilised.

**Proof.** Two electrons go into the lowered level: gain $2\beta^2/\Delta\varepsilon$. With four, the upper level is filled too; to the order of [Theorem 17.1](#thm-b2-frontier-orbitals-perturbation) the two shifts cancel, and with the overlap kept the upper level rises more than the lower falls ([Proposition 14.5](https://one-course.com/books/chemistry/3/en/chapter/14-molecular-orbitals-of-diatomic-molecules#prop-b2-diatomic-mos-asymmetry)): a net repulsion. ∎

![Interaction of two orbitals of neighbouring molecules. A filled orbital facing an empty one gives a net stabilisation; two filled orbitals repel, the upper level rising more than the lower one falls. This repulsion is the origin of steric hindrance between molecules.](https://one-course.com/images/onecourse/chapters/chemistry-3/b2-frontier-orbitals/fig-12061b3e6a2e.svg)

*Interaction of two orbitals of neighbouring molecules. A filled orbital facing an empty one gives a net stabilisation; two filled orbitals repel, the upper level rising more than the lower one falls. This repulsion is the origin of steric hindrance between molecules.*

## 17.2 Frontier orbitals

**Definition 17.3 (Frontier orbitals).**

The *HOMO* (highest occupied [molecular orbital](https://one-course.com/books/chemistry/3/en/chapter/14-molecular-orbitals-of-diatomic-molecules#def-b2-diatomic-mos-lcao)) and the *LUMO* (lowest unoccupied [molecular orbital](https://one-course.com/books/chemistry/3/en/chapter/14-molecular-orbitals-of-diatomic-molecules#def-b2-diatomic-mos-lcao)) of a molecule are its *frontier orbitals*.

**Proposition 17.4 (The dominant interaction).**

Between two closed-shell molecules, the stabilising interactions that matter most are between the [HOMO](#def-b2-frontier-orbitals-frontier) of one and the [LUMO](#def-b2-frontier-orbitals-frontier) of the other; of the two such pairs, the one with the smaller gap dominates. A nucleophile reacts through its [HOMO](#def-b2-frontier-orbitals-frontier), an electrophile through its [LUMO](#def-b2-frontier-orbitals-frontier).

**Argument.** Filled–filled pairs repel ([Proposition 17.2](#prop-b2-frontier-orbitals-four-electron)) and empty–empty pairs hold no electrons: only filled–empty pairs stabilise, each by $2\beta^2/\Delta\varepsilon$. The [HOMO](#def-b2-frontier-orbitals-frontier) is the highest filled level and the [LUMO](#def-b2-frontier-orbitals-frontier) the lowest empty one, so a HOMO–LUMO pair has the smallest gap among them; by the theorem, the smallest gap gives the largest term. ∎

**Definition 17.5 (Charge control and orbital control).**

A reaction is under *charge control* when the attraction between the charges of the two partners decides where they react, and under *orbital control* when the overlap of the [frontier orbitals](#def-b2-frontier-orbitals-frontier) decides it, the attack taking place where their coefficients are largest.

**Definition 17.6 (Hard and soft species).**

A *hard nucleophile* or *hard electrophile* is small, carries a concentrated charge and has a [HOMO](#def-b2-frontier-orbitals-frontier) (respectively a [LUMO](#def-b2-frontier-orbitals-frontier)) far from that of its partners: it reacts under [charge control](#def-b2-frontier-orbitals-control). A *soft nucleophile* or *soft electrophile* is large and polarisable, with a high [HOMO](#def-b2-frontier-orbitals-frontier) (respectively a low [LUMO](#def-b2-frontier-orbitals-frontier)): it reacts under [orbital control](#def-b2-frontier-orbitals-control). Hard reacts preferably with hard, soft with soft.

The hydroxide ion and the fluoride ion are [hard nucleophiles](#def-b2-frontier-orbitals-hard-soft), iodide and thiolates soft; a proton and a carbocation are [hard electrophiles](#def-b2-frontier-orbitals-hard-soft), the carbon of a halogenoalkane soft.

**Definition 17.7 (Ambident nucleophile).**

An *ambident nucleophile* has two nucleophilic atoms connected by conjugation, which can each attack an electrophile.

The cyanide ion is attacked at nitrogen, where the negative charge is larger, by [hard electrophiles](#def-b2-frontier-orbitals-hard-soft), and at carbon, where its [HOMO](#def-b2-frontier-orbitals-frontier) has its larger coefficient, by soft ones: a halogenoalkane gives a nitrile $\ce{R-C#N}$. Enolate ions, met in [Chapter 25](https://one-course.com/books/chemistry/3/en/chapter/25-enols-enolates-and-the-aldol-reaction#ch-b2-enolates-aldol), react at carbon or at oxygen in the same way.

**Method 17.8 (A frontier-orbital analysis).**

1. Identify the nucleophile (high [HOMO](#def-b2-frontier-orbitals-frontier) ) and the electrophile (low [LUMO](#def-b2-frontier-orbitals-frontier) ).
2. Draw the two [frontier orbitals](#def-b2-frontier-orbitals-frontier) with their coefficients and signs.
3. The reaction occurs where the overlap is largest: atoms with the largest coefficients, lobes of the same sign facing each other.
4. The direction of approach follows the shape of the [LUMO](#def-b2-frontier-orbitals-frontier) (perpendicular to a $\ce{C=O}$ plane, at the back of a $\ce{C-X}$ bond).
5. A smaller HOMO–LUMO gap means a faster reaction (other things being equal).

The direction of attack follows from the [LUMO](#def-b2-frontier-orbitals-frontier). The [LUMO](#def-b2-frontier-orbitals-frontier) of a carbonyl group is its $\pi^*$ orbital, larger on carbon and perpendicular to the plane: nucleophiles approach the carbon from above or below the plane, not along the $\ce{C=O}$ axis. The [LUMO](#def-b2-frontier-orbitals-frontier) of a halogenoalkane is the $\sigma^*$ orbital of the $\ce{C-X}$ bond, whose large lobe on carbon points away from X: the nucleophile attacks from the back, and the carbon is inverted — the stereochemistry of the bimolecular substitution of the Year 1 volume.

## 17.3 The Diels–Alder reaction

**Definition 17.9 (Concerted reaction).**

A *concerted reaction* makes and breaks all its bonds in a single step, through one transition state, without an intermediate.

**Definition 17.10 (Diels–Alder reaction).**

The *Diels–Alder reaction* is the concerted addition of a conjugated *diene*, in its s-cis conformation, to an alkene or alkyne, the *dienophile*, forming a six-membered ring with two new $\sigma$ bonds and one new $\pi$ bond.

![The Diels–Alder reaction of butadiene and ethene, written with curly arrows: three pairs of electrons move at once, in a cyclic, concerted step; two bonds form at the ends of the diene, and the π bond moves to its centre.](https://one-course.com/images/onecourse/chapters/chemistry-3/b2-frontier-orbitals/fig-516a046ceac3.svg)

*The [Diels–Alder reaction](#def-b2-frontier-orbitals-diels-alder) of butadiene and ethene, written with curly arrows: three pairs of electrons move at once, in a cyclic, concerted step; two $\sigma$ bonds form at the ends of the [diene](#def-b2-frontier-orbitals-diels-alder), and the $\pi$ bond moves to its centre.*

The dominant interaction is between the [HOMO](#def-b2-frontier-orbitals-frontier) of the [diene](#def-b2-frontier-orbitals-diels-alder), $\psi_2$, and the [LUMO](#def-b2-frontier-orbitals-frontier) of the [dienophile](#def-b2-frontier-orbitals-diels-alder), $\pi^*$. Their lobes at the ends of the [diene](#def-b2-frontier-orbitals-diels-alder) and on the two carbons of the [dienophile](#def-b2-frontier-orbitals-diels-alder) have matching signs when the [dienophile](#def-b2-frontier-orbitals-diels-alder) approaches the face of the [diene](#def-b2-frontier-orbitals-diels-alder): both new bonds can form at once, on the same face of each partner.

![Frontier orbitals of butadiene and ethene, lobes in proportion to their Hückel coefficients. Facing each other, the end lobes of the diene’s HOMO and the lobes of the dienophile’s LUMO have the same signs at both ends: the two bonds can form together, on the same face of each partner.](https://one-course.com/images/onecourse/chapters/chemistry-3/b2-frontier-orbitals/fig-1c94fc74acc6.svg)

*[Frontier orbitals](#def-b2-frontier-orbitals-frontier) of butadiene and ethene, lobes in proportion to their Hückel coefficients. Facing each other, the end lobes of the [diene](#def-b2-frontier-orbitals-diels-alder)’s [HOMO](#def-b2-frontier-orbitals-frontier) and the lobes of the [dienophile](#def-b2-frontier-orbitals-diels-alder)’s [LUMO](#def-b2-frontier-orbitals-frontier) have the same signs at both ends: the two $\sigma$ bonds can form together, on the same face of each partner.*

**Proposition 17.11 (Stereospecificity).**

The [Diels–Alder reaction](#def-b2-frontier-orbitals-diels-alder) is stereospecific: substituents cis on the [dienophile](#def-b2-frontier-orbitals-diels-alder) are cis in the product, trans substituents remain trans.

**Proof.** The reaction is concerted and both new bonds form on the same face of the [dienophile](#def-b2-frontier-orbitals-diels-alder): its two carbons never rotate with respect to each other, and the relative positions of their substituents are carried into the ring. ∎

**Proposition 17.12 (Regioselectivity).**

With unsymmetrical partners, the major product joins the atom of the [diene](#def-b2-frontier-orbitals-diels-alder) with the largest coefficient in its [HOMO](#def-b2-frontier-orbitals-frontier) to the atom of the [dienophile](#def-b2-frontier-orbitals-diels-alder) with the largest coefficient in its [LUMO](#def-b2-frontier-orbitals-frontier).

**Argument.** In the transition state the two new bonds are not yet equally formed; the stabilisation $2\beta^2/\Delta\varepsilon$ is larger when the larger coefficients overlap ($\beta$ grows with the product of the coefficients of the overlapping atoms), so that orientation is reached at lower energy. ∎

![Hückel model with heteroatom parameters (_ O = + 2, _ CO = 0.8 for the ether oxygen; _ O = +, _ CO = for the carbonyl oxygen; a model). The diene’s HOMO is largest on C4, the end far from the methoxy group (0.60 against 0.51); the dienophile’s LUMO is largest on the carbon (0.66). They bond together: the methoxy and aldehyde groups end up on neighbouring carbons of the ring.](https://one-course.com/images/onecourse/chapters/chemistry-3/b2-frontier-orbitals/fig-b28f93229eac.svg)

![Hückel model with heteroatom parameters (_ O = + 2, _ CO = 0.8 for the ether oxygen; _ O = +, _ CO = for the carbonyl oxygen; a model). The diene’s HOMO is largest on C4, the end far from the methoxy group (0.60 against 0.51); the dienophile’s LUMO is largest on the carbon (0.66). They bond together: the methoxy and aldehyde groups end up on neighbouring carbons of the ring.](https://one-course.com/images/onecourse/chapters/chemistry-3/b2-frontier-orbitals/fig-168bc0259b39.svg)

*Hückel model with heteroatom parameters ($\alpha_{\ce{O}} = \alpha + 2\beta$, $\beta_{\ce{CO}} = 0.8\beta$ for the ether oxygen; $\alpha_{\ce{O}} = \alpha + \beta$, $\beta_{\ce{CO}} =
\beta$ for the carbonyl oxygen; a model). The [diene](#def-b2-frontier-orbitals-diels-alder)’s [HOMO](#def-b2-frontier-orbitals-frontier) is largest on C4, the end far from the methoxy group (0.60 against 0.51); the [dienophile](#def-b2-frontier-orbitals-diels-alder)’s [LUMO](#def-b2-frontier-orbitals-frontier) is largest on the $\beta$ carbon (0.66). They bond together: the methoxy and aldehyde groups end up on neighbouring carbons of the ring.*

The donor group raises the [diene](#def-b2-frontier-orbitals-diels-alder)’s [HOMO](#def-b2-frontier-orbitals-frontier) ($m = 0.48$ instead of 0.62) and the acceptor lowers the [dienophile](#def-b2-frontier-orbitals-diels-alder)’s [LUMO](#def-b2-frontier-orbitals-frontier) ($m = -0.35$ instead of $-1$): the gap narrows, and such pairs react much faster than butadiene with ethene. A [diene](#def-b2-frontier-orbitals-diels-alder) rich in electrons and a [dienophile](#def-b2-frontier-orbitals-diels-alder) poor in electrons is the typical combination.

**Definition 17.13 (Endo and exo adducts).**

When a cyclic [diene](#def-b2-frontier-orbitals-diels-alder) adds to a [dienophile](#def-b2-frontier-orbitals-diels-alder) carrying an unsaturated substituent, the *endo adduct* has that substituent pointing towards the newly formed double bond (under the [diene](#def-b2-frontier-orbitals-diels-alder) in the transition state), the *exo adduct* away from it. The *endo rule* states that the endo adduct is formed faster.

**Proposition 17.14 (The endo rule).**

Under kinetic control, the [endo adduct](#def-b2-frontier-orbitals-endo) is the major product, although the [exo adduct](#def-b2-frontier-orbitals-endo) is often the more stable.

**Proof.** *Admitted at this level.* ∎

The usual explanation is a secondary overlap, in the endo approach, between the lobes of the substituent’s $\pi$ system and those of the central atoms of the [diene](#def-b2-frontier-orbitals-diels-alder)’s [HOMO](#def-b2-frontier-orbitals-frontier); it lowers the endo transition state without forming a bond. The rule is empirical and has exceptions; the Year 3 volume treats these reactions with the symmetry of their orbitals.

![Endo and exo approaches of maleic anhydride to cyclopentadiene, schematic. The forming bonds are dashed. In the endo approach the carbonyl groups lie under the diene, and their π orbitals overlap with its central carbons (dotted, secondary overlap); in the exo approach they point away.](https://one-course.com/images/onecourse/chapters/chemistry-3/b2-frontier-orbitals/fig-c3d814fcb7e5.svg)

*Endo and exo approaches of maleic anhydride to cyclopentadiene, schematic. The forming bonds are dashed. In the endo approach the carbonyl groups lie under the [diene](#def-b2-frontier-orbitals-diels-alder), and their $\pi$ orbitals overlap with its central carbons (dotted, secondary overlap); in the exo approach they point away.*

**Method 17.15 (Drawing a Diels–Alder product).**

1. Put the [diene](#def-b2-frontier-orbitals-diels-alder) in its s-cis conformation, the [dienophile](#def-b2-frontier-orbitals-diels-alder) facing its ends.
2. Draw the two new $\sigma$ bonds from the [diene](#def-b2-frontier-orbitals-diels-alder) ’s ends to the [dienophile](#def-b2-frontier-orbitals-diels-alder) ’s carbons, and the new $\pi$ bond between C2 and C3 of the [diene](#def-b2-frontier-orbitals-diels-alder) .
3. Keep the [dienophile](#def-b2-frontier-orbitals-diels-alder) ’s substituents on the same side (cis stays cis).
4. For unsymmetrical partners, join the largest coefficients (“ortho” or “para” products for 1- or 2-substituted [dienes](#def-b2-frontier-orbitals-diels-alder) ).
5. With a cyclic [diene](#def-b2-frontier-orbitals-diels-alder) , put the unsaturated substituent endo.

**In the lab — Cracking dicyclopentadiene.**

Cyclopentadiene is sold as its dimer and regenerated just before use: the dimer is heated to its boiling point (about $170{}^{\circ}\mathrm{C}$) in a flask fitted with a fractionating column, where it splits back into the monomer (a retro-Diels–Alder reaction), which distils at $41{}^{\circ}\mathrm{C}$ and is collected in a receiver cooled in ice. The monomer dimerises again within hours at room temperature and is used at once. Both compounds are flammable and harmful; the work is done in a fume hood.

**Safety.**

![](https://one-course.com/images/onecourse/chapters/chemistry-3/b2-frontier-orbitals/fig-4b496db0d6c3.svg)

![](https://one-course.com/images/onecourse/chapters/chemistry-3/b2-frontier-orbitals/fig-58320b3f229b.svg)

![](https://one-course.com/images/onecourse/chapters/chemistry-3/b2-frontier-orbitals/fig-748906458fb6.svg)

Cyclopentadiene and its dimer are highly flammable and toxic by inhalation; maleic anhydride is corrosive and a respiratory sensitiser. They are handled in a fume hood, with gloves and eye protection, away from flames.

## 17.4 Exercises

**Exercise 17.1 ★.**

Give the [HOMO](#def-b2-frontier-orbitals-frontier) and the [LUMO](#def-b2-frontier-orbitals-frontier) (energies in Hückel units) of ethene, of the allyl anion and of butadiene.

**Solution of Exercise 17.1.**

Ethene: [HOMO](#def-b2-frontier-orbitals-frontier) $\alpha + \beta$, [LUMO](#def-b2-frontier-orbitals-frontier) $\alpha - \beta$. Allyl anion (four electrons): [HOMO](#def-b2-frontier-orbitals-frontier) $\alpha$ (the nonbonding level), [LUMO](#def-b2-frontier-orbitals-frontier) $\alpha - 1.414\beta$. Butadiene: [HOMO](#def-b2-frontier-orbitals-frontier) $\alpha + 0.618\beta$, [LUMO](#def-b2-frontier-orbitals-frontier) $\alpha -
0.618\beta$.

**Exercise 17.2 ★.**

Classify as hard or soft: $\ce{OH-}$, $\ce{I-}$, $\ce{H+}$, a thiolate $\ce{RS-}$, the carbon of iodomethane, $\ce{F-}$.

**Solution of Exercise 17.2.**

Hard: $\ce{OH-}$, $\ce{H+}$, $\ce{F-}$. Soft: $\ce{I-}$, $\ce{RS-}$, the carbon of iodomethane.

**Exercise 17.3 ★.**

Which of these [dienes](#def-b2-frontier-orbitals-diels-alder) can take part in a [Diels–Alder reaction](#def-b2-frontier-orbitals-diels-alder): buta-1,3-diene, cyclopentadiene, penta-1,4-diene, (2*Z*,4*Z*)-hexa-2,4-diene in its s-cis form?

**Solution of Exercise 17.3.**

Butadiene (s-cis conformer accessible) and cyclopentadiene (locked s-cis) react; penta-1,4-diene is not conjugated and does not. The (2*Z*,4*Z*) [diene](#def-b2-frontier-orbitals-diels-alder) can reach the s-cis form only by pushing its two inner methyl groups into each other: it reacts very poorly.

**Exercise 17.4 ★.**

Draw the product of butadiene with propenenitrile $\ce{CH2=CH-C#N}$.

**Solution of Exercise 17.4.**

Cyclohex-3-ene-1-carbonitrile: a six-membered ring, double bond between the former C2 and C3 of the [diene](#def-b2-frontier-orbitals-diels-alder), the $\ce{C#N}$ group on one of the two ring carbons formed from the [dienophile](#def-b2-frontier-orbitals-diels-alder).

**Exercise 17.5 ★★.**

Two orbitals at $-10$ and $-2\,\mathrm{eV}$ interact with $\beta = -1.0\,\mathrm{eV}$ (exercise data). Compute the perturbative stabilisation of two electrons, then the exact one.

**Solution of Exercise 17.5.**

$\Delta\varepsilon = 8\,\mathrm{eV}$: perturbative $2\beta^2/\Delta\varepsilon = 0.25\,\mathrm{eV}$. Exact: lower level $-6 - \sqrt{16 + 1} = -10.123\,\mathrm{eV}$, gain $2 \times 0.123 = 0.246\,\mathrm{eV}$.

**Exercise 17.6 ★★.**

The cyanide ion reacts with iodomethane to give ethanenitrile $\ce{CH3-C#N}$, but with a carbocation in a strongly ionising solvent it gives some isonitrile $\ce{R-N#C}$. Explain.

**Solution of Exercise 17.6.**

Iodomethane is a [soft electrophile](#def-b2-frontier-orbitals-hard-soft): [orbital control](#def-b2-frontier-orbitals-control), attack by the atom with the larger [HOMO](#def-b2-frontier-orbitals-frontier) coefficient, carbon. A free carbocation is a [hard electrophile](#def-b2-frontier-orbitals-hard-soft): [charge control](#def-b2-frontier-orbitals-control), attack in part by nitrogen, which carries more negative charge.

**Exercise 17.7 ★★.**

Using the coefficients of the chapter, predict the major product of 1-methoxybutadiene with propenal.

**Solution of Exercise 17.7.**

C4 of the [diene](#def-b2-frontier-orbitals-diels-alder) (largest [HOMO](#def-b2-frontier-orbitals-frontier) coefficient) bonds to the $\beta$ carbon of propenal (largest [LUMO](#def-b2-frontier-orbitals-frontier) coefficient): 2-methoxycyclohex-3-ene-1-carbaldehyde, the two substituents on neighbouring carbons (“ortho” product).

**Exercise 17.8 ★★.**

Draw the [endo adduct](#def-b2-frontier-orbitals-endo) of cyclopentadiene with methyl propenoate.

**Solution of Exercise 17.8.**

A bicyclo[2.2.1]heptene (norbornene) skeleton with the ester group on a carbon of the former [dienophile](#def-b2-frontier-orbitals-diels-alder), pointing towards the new $\ce{C=C}$ bond, under the six-membered ring (endo), on the side opposite the $\ce{CH2}$ bridge.

**Exercise 17.9 ★★.**

Why does maleic anhydride react with cyclopentadiene at room temperature, while ethene needs heating under pressure?

**Solution of Exercise 17.9.**

The two carbonyl groups lower the [LUMO](#def-b2-frontier-orbitals-frontier) of the [dienophile](#def-b2-frontier-orbitals-diels-alder): its gap with the [HOMO](#def-b2-frontier-orbitals-frontier) of cyclopentadiene is much smaller than that of ethene, the stabilisation $\beta^2/\Delta\varepsilon$ of the transition state is larger, and the barrier lower.

**Exercise 17.10 ★★★.**

Cyclopentadiene reacts with dimethyl maleate (cis diester) and with dimethyl fumarate (trans diester). Draw both products and say how many stereoisomers each gives.

**Solution of Exercise 17.10.**

The reaction is stereospecific: the maleate gives the adduct with both ester groups cis (endo,endo as the major product; it is achiral, a meso compound); the fumarate gives the trans adduct, one ester endo and one exo, formed as a pair of enantiomers (racemic).

**Exercise 17.11 ★★★.**

The [Diels–Alder reaction](#def-b2-frontier-orbitals-diels-alder) has $\Delta_r H^\circ < 0$ and $\Delta_r S^\circ < 0$. Explain the signs and why the reverse reaction becomes favourable at high temperature.

**Solution of Exercise 17.11.**

Two $\pi$ bonds become two stronger $\sigma$ bonds: $\Delta_r H^\circ < 0$. Two molecules become one: $\Delta_r S^\circ < 0$. $\Delta_r G^\circ = \Delta_r H^\circ - T\Delta_r S^\circ$ grows with $T$ and becomes positive above $T_i = \Delta_r H^\circ/\Delta_r S^\circ$: at high temperature the adduct splits back (retro-Diels–Alder).

**Exercise 17.12 ★★★.**

In hydrazine $\ce{H2N-NH2}$, each nitrogen carries a lone pair. Using the four-electron interaction, explain why the molecule avoids the conformation in which the two lone pairs are parallel.

**Solution of Exercise 17.12.**

Two filled lone-pair orbitals side by side form a four-electron interaction, which repels. The molecule turns about the $\ce{N-N}$ bond until the lone pairs are roughly perpendicular (a gauche conformation), where their overlap, and the repulsion, is small.

## 17.5 Problem: Cracking Cyclopentadiene

**Problem 17.1.**

Weekend problem — the dimerisation of cyclopentadiene as a Diels–Alder reaction, the thermodynamics of cracking, the frontier orbitals of cyclopentadiene and maleic anhydride, and the stereochemistry of their adduct

Data: boiling points, cyclopentadiene $41{}^{\circ}\mathrm{C}$, dicyclopentadiene about $170{}^{\circ}\mathrm{C}$. Hückel model energies (a model): cyclopentadiene, treated as a butadiene unit, [HOMO](#def-b2-frontier-orbitals-frontier) $\alpha + 0.62\beta$ and [LUMO](#def-b2-frontier-orbitals-frontier) $\alpha - 0.62\beta$; maleic anhydride, [LUMO](#def-b2-frontier-orbitals-frontier) about $\alpha - 0.35\beta$.

**Part I — The dimer.**

1. Draw cyclopentadiene and show that its [diene](#def-b2-frontier-orbitals-diels-alder) unit is held s-cis.
2. In the dimerisation, one molecule is the [diene](#def-b2-frontier-orbitals-diels-alder) . What is the other?
3. Draw the dimer and number the new bonds.
4. Which adduct, endo or exo, forms at room temperature, and why?
5. Is the dimerisation stereospecific? Explain with the mechanism.
6. Why does the dimerisation not need a catalyst?

**Part II — Thermodynamics of cracking.**

7. Give the sign of $\Delta_r H^\circ$ of the dimerisation, from the bonds formed and broken.
8. Give the sign of $\Delta_r S^\circ$ .
9. Write $\Delta_r G^\circ(T)$ and show that it changes sign at a temperature $T_i$ .
10. Why is the dimer stable at room temperature, and the monomer favoured when hot?
11. In the cracking set-up, why does distilling the monomer as it forms drive the reaction?
12. Why must the monomer be kept cold and used quickly?

**Part III — [Frontier orbitals](#def-b2-frontier-orbitals-frontier).**

13. For cyclopentadiene reacting with itself, compute the HOMO–LUMO gap in units of $|\beta|$ .
14. For cyclopentadiene with maleic anhydride, compute the gap between the [diene](#def-b2-frontier-orbitals-diels-alder) ’s [HOMO](#def-b2-frontier-orbitals-frontier) and the anhydride’s [LUMO](#def-b2-frontier-orbitals-frontier) .
15. Which pair reacts faster? Explain.
16. Why do the two carbonyl groups of maleic anhydride lower its [LUMO](#def-b2-frontier-orbitals-frontier) ?
17. Which orbital of maleic anhydride gives the secondary overlap of the endo approach?

**Part IV — The adduct with maleic anhydride.**

18. Draw the [endo adduct](#def-b2-frontier-orbitals-endo) .
19. Mark its stereocentres.
20. Is the adduct chiral? (Look for a mirror plane.)
21. Why do the two hydrogens of the former [dienophile](#def-b2-frontier-orbitals-diels-alder) end up on the same side of the ring?
22. What would the [exo adduct](#def-b2-frontier-orbitals-endo) look like?
23. Can the endo and [exo adducts](#def-b2-frontier-orbitals-endo) interconvert at room temperature? Why?
24. How would the anhydride react with water, and what product would form?
25. State the number of stereocentres of the [endo adduct](#def-b2-frontier-orbitals-endo) of cyclopentadiene and maleic anhydride.

**Solution of Problem 17.1.**

**1.** A five-membered ring with two conjugated double bonds and a $\ce{CH2}$: the ring holds the [diene](#def-b2-frontier-orbitals-diels-alder) unit in the s-cis conformation. **2.** The [dienophile](#def-b2-frontier-orbitals-diels-alder), through one of its double bonds. **3.** A norbornene skeleton fused to a cyclopentene ring; the two new $\sigma$ bonds join the ends of the [diene](#def-b2-frontier-orbitals-diels-alder) to the two carbons of the [dienophile](#def-b2-frontier-orbitals-diels-alder)’s double bond. **4.** The [endo adduct](#def-b2-frontier-orbitals-endo) ([endo rule](#def-b2-frontier-orbitals-endo)): the remaining ring of the [dienophile](#def-b2-frontier-orbitals-diels-alder) lies under the [diene](#def-b2-frontier-orbitals-diels-alder) in the transition state. **5.** Yes: it is concerted, both bonds form on the same face of each partner, and the geometry of the [dienophile](#def-b2-frontier-orbitals-diels-alder) is kept. **6.** Cyclopentadiene is both a good [diene](#def-b2-frontier-orbitals-diels-alder) (locked s-cis) and a [dienophile](#def-b2-frontier-orbitals-diels-alder), and the reaction is concerted, with no charged intermediate to stabilise. **7.** Negative: two $\pi$ bonds are replaced by two $\sigma$ bonds. **8.** Negative: two molecules give one. **9.** $\Delta_r G^\circ = \Delta_r H^\circ - T\Delta_r S^\circ$ with both terms negative: negative at low $T$, zero at $T_i = \Delta_r H^\circ/\Delta_r S^\circ$, positive above. **10.** At room temperature $T < T_i$: dimerisation is favoured, though slow. Near the boiling point of the dimer the equilibrium favours the monomer, and it is reached quickly. **11.** The monomer leaves the hot mixture as vapour: removing a product keeps the equilibrium shifting towards the monomer (Le Chatelier). **12.** At room temperature it dimerises again; cold slows that reaction. **13.** $0.62 - (-0.62) = 1.24|\beta|$. **14.** $0.62 - (-0.35) = 0.97|\beta|$. **15.** Cyclopentadiene with maleic anhydride: the smaller gap gives a larger stabilisation of the transition state, a faster reaction. **16.** They are conjugated with the $\ce{C=C}$ bond and electron-withdrawing: as in propenal, they draw the $\pi^*$ level down. **17.** Its [LUMO](#def-b2-frontier-orbitals-frontier), which has lobes on the carbonyl carbons facing the central carbons of the [diene](#def-b2-frontier-orbitals-diels-alder)’s [HOMO](#def-b2-frontier-orbitals-frontier). **18.** Norbornene skeleton; the anhydride ring under the new double bond, opposite the $\ce{CH2}$ bridge. **19.** The two bridgehead carbons and the two carbons carrying the anhydride: four stereocentres. **20.** No: a mirror plane passes through the $\ce{CH2}$ bridge and between the two halves of the molecule; it is a meso compound. **21.** They were cis on the [dienophile](#def-b2-frontier-orbitals-diels-alder), and the concerted addition keeps them cis. **22.** The same skeleton with the anhydride ring on the side of the $\ce{CH2}$ bridge. **23.** No: changing endo to exo would mean breaking and remaking $\ce{C-C}$ bonds, through the retro-reaction, which needs heating. **24.** Water opens the anhydride: the cis dicarboxylic acid, both $\ce{COOH}$ groups endo. **25.** The [endo adduct](#def-b2-frontier-orbitals-endo) has $\boldsymbol{4}$ stereocentres.