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Chemistry · Glossary

What is Decarboxylation?

Also known as: malonic ester synthesis

Definition 25.7 University Chemistry — Year 2 · Chapter 25 — Enols, Enolates and the Aldol Reaction

A decarboxylation removes a carboxyl group as COX2\ce{CO2}. In the malonic ester synthesis, diethyl propanedioate is deprotonated, alkylated, hydrolysed to the substituted propanedioic acid and decarboxylated by heating, giving a carboxylic acid RCHX2COOH\ce{RCH2COOH}.

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