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Chemistry · Glossary

What is Metallodrugs?

Also known as: metallodrug

Definition 24.17 University Chemistry — Year 3 · Chapter 24 — Bioinorganic Chemistry

A metallodrug is a drug whose activity depends on a metal ion or a metal complex.

The 1,2-intrastrand cross-link made by cisplatin, schematic: after losing its two chlorides, platinum binds the N7 atoms of two adjacent guanines of one strand, keeping its two cis ammine ligands. The real adduct bends the double helix.
The 1,2-intrastrand cross-link made by cisplatin, schematic: after losing its two chlorides, platinum binds the N7 atoms of two adjacent guanines of one strand, keeping its two cis ammine ligands. The real adduct bends the double helix.
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