সব বই

পেশাদার

1 Markets I: The Ecosystem and Exchange-Traded Marketsবাজার অনলাইন 2 Markets II: Rates, FX and Creditবাজার অনলাইন 3 Markets III: Commodities, Energy and Cryptoবাজার অনলাইন 4 Quantitative Methodsপদ্ধতি অনলাইন 5 Derivatives and Volatilityডেরিভেটিভস অনলাইন 6 Rates, Credit, XVA and Riskসুদহার, ঋণ ও ঝুঁকি অনলাইন 7 Research Craft: Predictors, Backtests, Measurement, Portfoliosগবেষণা অনলাইন 8 Strategies I: Equities and Futuresকৌশল অনলাইন 9 Strategies II: Volatility, Relative Value, Macro and the Bank Desksকৌশল অনলাইন 10 Microstructure and Executionএক্সিকিউশন অনলাইন 11 Market Making and High-Frequency Tradingমার্কেট মেকিং অনলাইন 12 Machine Learning for Marketsমেশিন লার্নিং অনলাইন 13 Low-Latency Softwareপ্রযুক্তি অনলাইন 14 Networks, Hardware and Trading Infrastructureপ্রযুক্তি অনলাইন 15 Research, Data and Risk Platformsপ্রযুক্তি অনলাইন 16 The Desk and the Firmপ্রতিষ্ঠান অনলাইন 17 The Industry: Firms, Roles and Careersক্যারিয়ার অনলাইন 18 Interviews I: Maths, Probability and Speedক্যারিয়ার অনলাইন 19 Interviews II: Markets, Trading Games and the Final Roundক্যারিয়ার অনলাইন 20 Interviews III: Codeক্যারিয়ার অনলাইন
অ্যাপ পরিচিতি Coach সাইন ইন পড়া শুরু করো

বইগুলো এখনো বাংলা ভাষায় পাওয়া যায় না — ইংরেজি সংস্করণ দেখানো হচ্ছে।

Biology · পরিভাষা

Nucleosome and chromatin কী?

Definition 1.1 University Biology — Year 3 · অধ্যায় 1 — Chromatin and Epigenetics

Chromatin is the complex of DNA with proteins in which the genome exists in a eukaryotic nucleus. Its repeating unit is the nucleosome: 147 bp147\,\mathrm{bp} of DNA wound in 1.651.65 left-handed turns around a histone octamer — two copies each of the small, very basic proteins H2A, H2B, H3 and H4 — followed by a linker of 20 to 60 bp20\text{ to }60\,\mathrm{bp} to the next nucleosome. A fifth histone, H1, binds the linker where it enters and leaves the core and helps the beads pack against one another. Each core histone carries an unstructured amino-terminal tail of some 20 to 4020\text{ to }40 residues that projects out of the particle. Chromatin that stains lightly, is loosely packed and is transcribed is euchromatin; densely packed, late-replicating and largely silent chromatin, at centromeres, telomeres and repeated sequences, is heterochromatin.

The 10\, nm fibre: nucleosome cores (blue) on a continuous DNA (red), each bead a histone octamer with its tails (orange) projecting out, linker histone H1 (green) at the entry–exit point. About six nucleosomes occupy the length that 1200\, bp of naked DNA would.
The 10 nm10\,\mathrm{nm} fibre: nucleosome cores (blue) on a continuous DNA (red), each bead a histone octamer with its tails (orange) projecting out, linker histone H1 (green) at the entry–exit point. About six nucleosomes occupy the length that 1200 bp1200\,\mathrm{bp} of naked DNA would.
Chromatin at the molecular scale: the double helix wound around successive histone cores, the “beads on a string” that the nuclease ladder revealed.
Chromatin at the molecular scale: the double helix wound around successive histone cores, the “beads on a string” that the nuclease ladder revealed.

উদাহরণ

Example 1.3 (Two metres in ten micrometres)

A human diploid nucleus holds 6.4×1096.4\times 10^{9} base pairs. At 0.34 nm0.34\,\mathrm{nm} per base pair that is 2.2 m2.2\,\mathrm{m} of double helix, in a nucleus about 10 µm10\,\text{µ}\mathrm{m} across. It is packed into 6.4×109/200≈3.2×1076.4\times 10^{9}/200 \approx 3.2\times 10^{7} nucleosomes, each carrying about 108 kDa108\,\mathrm{kDa} of histone against 96 kDa96\,\mathrm{kDa} of DNA (147 bp147\,\mathrm{bp} at 650 Da650\,\mathrm{Da} per pair): the nucleus contains roughly as much histone as DNA by mass. The DNA itself, treated as a cylinder 2 nm2\,\mathrm{nm} across, has a volume of only about 7 µm37\,\text{µ}\mathrm{m}^{3}, some 1 %1\,\% of a spherical nucleus of radius 5 µm5\,\text{µ}\mathrm{m}; the packing problem is one of entanglement and access, not of room.

প্রসঙ্গসহ পড়ো →