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Chemistry · Glossary

What is Electrophilic activation?

Definition 23.1 University Chemistry — Year 1 · Chapter 23 — Carbonyls: Nucleophilic Additions, Acetals and Protection

Electrophilic activation of a carbonyl group is its protonation (or its coordination to a Lewis acid) on oxygen. The cation C=OHX+\ce{C=OH+}, whose positive charge is shared by carbon through the resonance structure CX+−OH\ce{C+-OH}, is attacked even by weak nucleophiles.

Activation of an aldehyde by acid: protonation of the oxygen produces a cation whose resonance structure carries the charge on carbon.
Activation of an aldehyde by acid: protonation of the oxygen produces a cation whose resonance structure carries the charge on carbon.
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