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Chemistry · Glossary

What is Resolutions?

Also known as: resolution of a racemate · kinetic resolution · dynamic kinetic resolution

Definition 28.13 University Chemistry — Year 3 · Chapter 28 — Asymmetric Synthesis

The resolution of a racemate is its separation into enantiomers, classically by crystallising diastereomeric salts with an enantiopure acid or base. In a kinetic resolution the two enantiomers react at different rates with a chiral reagent or catalyst, with selectivity s=kfast/kslows = k_{\mathrm{fast}}/k_{\mathrm{slow}}. In a dynamic kinetic resolution the substrate enantiomers interconvert fast while one of them reacts.

Kinetic resolution: ee of the remaining substrate (solid) and of the product (dashed) against conversion, for three selectivities. The substrate can always be made enantiopure by going far enough, at the cost of yield; the product is purest at low conversion.
Kinetic resolution: ee of the remaining substrate (solid) and of the product (dashed) against conversion, for three selectivities. The substrate can always be made enantiopure by going far enough, at the cost of yield; the product is purest at low conversion.
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