Two genes on the same chromosome are linked: their alleles tend to travel together into the gametes, and a dihybrid makes more parental gametes (, ) than recombinant ones (, ). Recombinants arise only when a crossover falls between the two loci, so their frequency — counted directly in a test cross — measures the distance: ranges from 0 (complete linkage) to (genes so far apart, or on different chromosomes, that they assort independently). The map distance unit is the centimorgan (cM): is recombination for closely linked genes; in humans is about a million base pairs. Linkage was the first proof that genes lie in a line on the chromosome.
Biology · Glossary