Biology · Glossary

What is Motor proteins?

Definition 9.5 University Biology — Year 3 · Chapter 9 — Cytoskeleton Dynamics and Cell Motility

A motor protein converts the free energy of ATP hydrolysis into directed movement along a filament: myosins along actin (myosin II, the muscle and contractile motor, toward the barbed end; myosin V, a two-headed vesicle carrier stepping 36nm36\,\mathrm{nm}), kinesins along microtubules toward the plus end (kinesin-1 steps 8nm8\,\mathrm{nm}, one tubulin dimer, per ATP, hand over hand, at about 800nm/s800\,\mathrm{nm}/\mathrm{s}), and dyneins toward the minus end (cytoplasmic dynein, with its adaptor dynactin, hauls cargo back to the cell centre; axonemal dyneins bend cilia). A motor is processive if it takes many steps before detaching: kinesin-1 walks about a micrometre, a hundred steps, alone; a single myosin II head takes one stroke and lets go, so muscle needs hundreds of heads working on one filament. Motors read the polarity of the track, so a cell’s geography — plus ends at the periphery, minus ends at the centre — is a map of where each motor will take its cargo.

Kinesin on its track and its footprint in an optical trap. The two heads alternate, each step advancing the motor by one tubulin dimer, 8\, nm; at low ATP the steps are separated by waits for the next nucleotide and the staircase is seen directly.
Kinesin on its track and its footprint in an optical trap. The two heads alternate, each step advancing the motor by one tubulin dimer, 8nm8\,\mathrm{nm}; at low ATP the steps are separated by waits for the next nucleotide and the staircase is seen directly.
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