Biology · Glossary

What is Functional groups?

Also known as: functional group

Definition 8.12 University Biology — Year 1 · Chapter 8 — Water and Small Biomolecules

The organic molecules of the cell are carbon skeletons bearing a small set of functional groups that determine their chemistry:

groupformulapropertyfound in
hydroxylOH-\mathrm{OH}polar, H-bondingsugars, alcohols
carbonyl> ⁣C=O>\!\mathrm{C{=}O}polar, reactivealdoses, ketoses
carboxylCOOH-\mathrm{COOH}acid (pKa4K_a \approx 4)fatty acids, amino acids
aminoNH2-\mathrm{NH_2}base (pKa9K_a \approx 9)amino acids
phosphateOPO32-\mathrm{OPO_3^{2-}}charged, energy-rich linksnucleotides, ATP
sulfhydrylSH-\mathrm{SH}forms S–S bridgescysteine
methylCH3-\mathrm{CH_3}non-polarlipids, DNA marks

At the pH of the cell carboxyl groups are ionised (COO-\mathrm{COO^-}) and amino groups protonated (NH3+-\mathrm{NH_3^+}).

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