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Biology · Glossary

What is Functional groups?

Also known as: functional group

Definition 8.12 University Biology — Year 1 · Chapter 8 — Water and Small Biomolecules

The organic molecules of the cell are carbon skeletons bearing a small set of functional groups that determine their chemistry:

groupformulapropertyfound in
hydroxyl−OH-\mathrm{OH}polar, H-bondingsugars, alcohols
carbonyl> ⁣C=O>\!\mathrm{C{=}O}polar, reactivealdoses, ketoses
carboxyl−COOH-\mathrm{COOH}acid (pKa≈4K_a \approx 4)fatty acids, amino acids
amino−NH2-\mathrm{NH_2}base (pKa≈9K_a \approx 9)amino acids
phosphate−OPO32−-\mathrm{OPO_3^{2-}}charged, energy-rich linksnucleotides, ATP
sulfhydryl−SH-\mathrm{SH}forms S–S bridgescysteine
methyl−CH3-\mathrm{CH_3}non-polarlipids, DNA marks

At the pH of the cell carboxyl groups are ionised (−COO−-\mathrm{COO^-}) and amino groups protonated (−NH3+-\mathrm{NH_3^+}).

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