Biology · Glossary

What is The envelope?

Definition 12.1 University Biology — Year 3 · Chapter 12 — Bacteriology: Growth, Physiology and Genetics

Every bacterium but a few is enclosed in a wall of peptidoglycan: chains of alternating N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides into a single molecule that surrounds the cell and resists the turgor pressure — several atmospheres — of the cytoplasm. Gram-positive bacteria have a thick wall of 20 to 80nm20\text{ to }80\,\mathrm{nm}, many layers, threaded with teichoic acids; Gram-negative bacteria have a thin wall of one or two layers and, outside it, a second lipid bilayer, the outer membrane, whose outer leaflet is lipopolysaccharide (LPS, endotoxin — the molecule that the innate immune system of Chapter 15 recognises and that causes septic shock), enclosing a periplasm. Porins in the outer membrane admit small molecules and exclude many antibiotics. Outside may lie a polysaccharide capsule against phagocytes, flagella for swimming (Chapter 9) and pili for attachment and conjugation. Inside, the chromosome — one circular molecule of 1 to 10Mb1\text{ to }10\,\mathrm{Mb} in most species — is folded into a nucleoid without a membrane, alongside plasmids. Some genera (Bacillus, Clostridium) can enclose a copy of the chromosome in a thick coat as an endospore, dehydrated and metabolically inert, which survives boiling, radiation and centuries of drought and germinates when nutrients return.

The two envelopes. Gram-positives wrap the membrane in many layers of peptidoglycan; Gram-negatives have a thin layer and an outer membrane of lipopolysaccharide pierced by porins, which keeps many antibiotics out and makes the endotoxin that causes septic shock.
The two envelopes. Gram-positives wrap the membrane in many layers of peptidoglycan; Gram-negatives have a thin layer and an outer membrane of lipopolysaccharide pierced by porins, which keeps many antibiotics out and makes the endotoxin that causes septic shock.
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