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Biology · পরিভাষা

Glycaemia কী?

Definition 32.1 High School Biology · অধ্যায় 32 — Blood Glucose and Diabetes

The glycaemia is the concentration of glucose in the blood plasma: about 1 g/L1\,\mathrm{g}/\mathrm{L} (5.5 mmol/L5.5\,\mathrm{mmol}/\mathrm{L}) before a meal in a healthy person, rising to 1.4 g/L1.4\,\mathrm{g}/\mathrm{L} within an hour of eating and returning within two, falling to 0.7 g/L0.7\,\mathrm{g}/\mathrm{L} after a day’s fast. Below 0.5 g/L0.5\,\mathrm{g}/\mathrm{L} the brain fails (confusion, then coma); above 1.8 g/L1.8\,\mathrm{g}/\mathrm{L} glucose spills into the urine, and years above 1.3 g/L1.3\,\mathrm{g}/\mathrm{L} damage vessels and nerves. Glycaemia is a regulated quantity: a value held near a set point by a system that measures it and corrects it.

উদাহরণ

Example 32.3 (A day of glycaemia)

Breakfast at 8: glycaemia rises from 0.90.9 to 1.3 g/L1.3\,\mathrm{g}/\mathrm{L} by 9 and is back at 1.01.0 by 10, the excess having gone into liver and muscle glycogen. From 10 to 13 the liver releases glycogen and the level holds near 0.90.9. A run at 17 draws 60 g60\,\mathrm{g} into the muscles in an hour; the liver empties half its store to keep pace, and the level dips to 0.80.8. Overnight, the liver makes new glucose from amino acids, and at 7 the level is 0.9 g/L0.9\,\mathrm{g}/\mathrm{L}. Three hundred grams have passed through a pool of five.

Example 32.5 (The loop in action)

After a meal the glycaemia climbs; within minutes the β\beta cells release insulin, the muscles and fat cells open their glucose transporters, the liver switches to making glycogen, and the level falls back — at which point insulin secretion falls too. Between meals the drift downward is met by glucagon, glycogen is broken down, and the level holds. Neither hormone is ever absent; their ratio moves, and the glycaemia follows it within a narrow band.

Example 32.8 (Managing a day with type 1)

A teenager with type 1 measures her glycaemia before each meal with a drop of blood, counts the carbohydrate on her plate, and injects a dose of fast insulin proportional to it — about one unit per 10 g10\,\mathrm{g} — plus a slow insulin once a day for the background. Too much insulin, or a missed meal, and the level falls below 0.6 g/L0.6\,\mathrm{g}/\mathrm{L}: sweating, trembling, confusion, corrected by sugar in minutes. Too little, and the level stays above 2 g/L2\,\mathrm{g}/\mathrm{L} with thirst and fatigue, and the vessels take the damage silently. She is doing, by hand, what her β\beta cells did by feedback.

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