Biology · Glossary

What is The mammalian lung?

Definition 21.7 University Biology — Year 1 · Chapter 21 — Respiratory Gas Exchange

A lung is an invagination of the body surface into a moist internal chamber, which keeps the surface wet in dry air. The mammalian lung is a tree of airways ending in some three hundred million alveoli, sacs 0.2mm0.2\,\mathrm{mm} across whose walls — one epithelial cell and one capillary endothelium, 0.5µm0.5\,\text{µ}\mathrm{m} in all — add up to 100m2100\,\mathrm{m}^{2} in a human, wrapped in a capillary net through which the whole cardiac output passes. It is ventilated tidally: the diaphragm and rib muscles enlarge the chest, air flows in; they relax, air flows out by the same path. A breath moves 500mL500\,\mathrm{mL}, of which 150mL150\,\mathrm{mL} only fills the airways (dead space) and never reaches an alveolus; the alveolar gas, renewed by a seventh at each breath, stays at PO2=13.3kPaP_{\mathrm{O_2}} = 13.3\,\mathrm{kPa} and PCO2=5.3kPaP_{\mathrm{CO_2}} = 5.3\,\mathrm{kPa} — the pressures the blood equilibrates with.

Alveoli at the end of an airway, wrapped in capillaries. The whole cardiac output spreads over a hundred square metres of this wall, a fraction of a second at a time.
Alveoli at the end of an airway, wrapped in capillaries. The whole cardiac output spreads over a hundred square metres of this wall, a fraction of a second at a time.

Examples

Example 21.13 (Altitude and depth)

At 4000m4000\,\mathrm{m} the air holds 12kPa12\,\mathrm{kPa} of oxygen and the alveoli 77\,: the carotid bodies drive ventilation up, which blows off CO2\mathrm{CO_2} and makes the blood alkaline — a brake the kidneys release over days by excreting bicarbonate; the red cells raise their BPG within days and the marrow raises haemoglobin within weeks (Chapter 12). A seal diving for twenty minutes does the opposite: it exhales before diving, slows its heart to a tenth, shuts the blood off from everything but brain and heart, and runs its muscles on the oxygen bound to their own myoglobin, ten times more concentrated than ours, and then on fermentation, tolerating a lactate the body clears at the surface. Its lungs collapse below 50m50\,\mathrm{m}, which keeps nitrogen out of its blood.

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